Read across approach toxicology

Author: nsem

August undefined, 2024

WebRead-across is one of the most frequently used alternative tools for hazard assessment, in particular for complex endpoints such as repeated dose or developmental and reproductive toxicity. Read-across extrapolates the outcome of a specific toxicological in vivo endpoint from tested (source) compounds to "similar" (target) compound (s). WebJun 10, 2013 · Considerations before embarking on a read-across approach have been discussed at length elsewhere [16,17,19, 20, 27]. The types of considerations vary to a degree depending on the decision context ...

A strategy for structuring and reporting a read-across

WebJun 23, 2024 · The concept of chemical similarity has many applications in several fields of cheminformatics. One common use of chemical similarity measurements, based on the principle that similar molecules have similar properties, is in the context of the read-across approach, where estimates of a specific endpoint for a chemical are obtained starting … WebThe use of toxicity data on a structurally-similar compound to evaluate a substance that has been inadequately tested – the so-called “read-across” approach – is a crucial part of the … ttfsfw01a

Approaches in metabolomics for regulatory toxicology applications …

WebJul 12, 2013 · Advancing the science of a read-across framework for evaluation of data-poor chemicals incorporating systematic and new approach methods. Regulatory Toxicology and Pharmacology 2024, 137 , 105293. ... Extending the Generalised Read-Across approach (GenRA): A systematic analysis of the impact of physicochemical property information on … WebFeb 6, 2024 · Toxicology and Environmental Research and Consulting, Dow Chemical, Midland, Michigan, USA. Search for more papers by this author. Lennart Weltje, ... In addition, the degree of validation needed to provide sufficient confidence in a given read-across approach has to be decided. Another complicating factor is the difference in validation ... WebComputational Toxicology 3 Definitions: Read-across • Read-across describes the method of filling a data gap whereby a chemical with existing data values is used to make a prediction for a ‘similar’ chemical. • A target chemical is a chemical which has a data gap that needs to be filled i.e. the subject of the read-across. • phoenix bus system

Dossier Evaluation Process principles applied by ECHA in …

Society of Toxicology (SOT)

Weba National Center for Computational Toxicology (NCCT), ... any read-across approach should be broadly based in scope or lim-ited to a speciﬁc endpoint. Patlewicz et al. [39,40] discussed the ... Web1 day ago · Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury … ttfs incWebNov 12, 2024 · The aim of regulatory toxicology is to prevent hazardous substances and products from producing adverse effects on human health and on the environment. 100 In … ttf tenis

"WebJun 19, 2024 · Read-Across Methodology in Toxicological Risk Assessment Introduction. Chemical risk assessment aims at compound-specific threshold values, like acceptable … " - Read across approach toxicology

Read across approach toxicology

Alternative Test Methods and Strategies to Reduce Vertebrate …

WebNov 12, 2024 · Chemical grouping and read-across Chemical grouping and read-across approaches take advantage of structural similarities between substances with known toxicology profiles and new chemical entities to infer the expected toxicological behaviour of the latter. 101 This strategy is commonly used in regulatory toxicology as an … WebJul 12, 2013 · The Chemical–Biological Read-Across (CBRA) approach infers each compound’s toxicity from both chemical and biological analogues whose similarities are …

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WebRead-across has generated much attention since it may be used as an alternative approach for addressing the information requirements under regulatory programmes, notably the EU's REACH regulation. WebToxicology Letters 116(S1), 61. Potts RO, Guy RH. (1992). Predicting skin permeability. ... The UK Environmental Agency have a similar approach to read across as the HSE though appropriate ecotoxicity tests such as acute toxicity to Daphnia form the basis of establishing the validity of their read acrosses.The approach is also a step-by-step ...

Webproposed read-across case, resulting in an output which is suitable for subsequent regulatory consideration of the read-across case. The approach reflects both a need to … WebComputational Toxicology Generalised Read-Across GenRA, research, implementation and practical application. ToxPi. PRIORITIZATION. Interactive Chemica Sl afety for Sustainability Web Application TOXCAST iCSS v0.5 Tool Tip Description of Assays (Data) or . Prioritization Mode whatever is being hovered over Desc Summary Log 80-05-7 80-05-1 80-05 ...

WebJan 1, 2024 · Integrating computational chemistry and toxicology can improve the read-across analog approach to fill data gaps in chemical safety assessment. ... The read-across approach starts with structural ... WebAug 8, 2024 · Read-across has become the essential technique to fill toxicological data gaps. Whilst the term “read-across” has been used since the 1980s, until recently it has …

WebWe present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active …

WebDec 21, 2024 · The Strategic Plan has three core components: (1) identifying, developing and integrating NAMs for TSCA decisions; (2) building confidence that the NAMs are scientifically reliable and relevant for TSCA decisions; and (3) implementing the reliable and relevant NAMs for TSCA decisions. On this page: Implementing the Strategic Plan ttfsfw08aWebJul 8, 2024 · Inspired by the increasingly used read-across approach, we created a new type of QSAR, which is based on similarity of chemicals and not on chemical descriptors. A landscape of the chemical universe using 10 million structures was calculated, when based on Tanimoto indices similar chemicals are close and dissimilar chemicals far from each … ttf sum19Webread-across hypothesis and the information requirement to be read across The RAAF defines two general read-across hypotheses: 1. (Bio)transformation into a common toxicant • Toxicokinetic information may support the approach 2. Different compounds have the same type of effects • Toxicodynamic information may support the approach ttftcutsWebAug 1, 2015 · Within the applicability domain of a chemical category, read-across can be performed to fill data gaps with a number of approaches which can be summarised into the following four techniques: (1) one-to-one read-across (i.e., one source substance used to make a prediction for a single target chemical), (2) phoenix bus pass costWebRead-across is one approach frequently used in the risk assessment of substances that lack information on their physical-chemical or toxicological properties, or their environmental … phoenix by league of legendsWebAug 8, 2024 · Read-across has become the essential technique to fill toxicological data gaps. Whilst the term “read-across” has been used since the 1980s, until recently it has been used in a relatively specialist context implying “accepted” structural similarity, particularly within well-defined chemical classes. phoenix by netrum lyricsWebRead-across (RAx) translates available information from well-characterized chemicals to a substance for which there is a toxicological data gap. The OECD is working on case … phoenix bus schedule