Gemcitabine and ferroptosis

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August undefined, 2024

WebJun 10, 2024 · Ferroptosis refers to a nonapoptotic, RCD procedure involving the abnormal metabolism of lipid oxides in cells catalyzed by iron ions or iron enzymes and has been identified recently. In this... Web1 day ago · The high expression of RRM2 and AURKA leads to poor prognosis, so more sensitive agents are needed to improve outcome and try to connect these drugs with ferroptosis therapy of LUAD at this time. Zhan et al. concluded that RRM2 is closely related to the drug resistance of many chemotherapeutic drugs [43], such as gemcitabine [44]. …

Cancer-associated fibroblasts suppress ferroptosis and induce ...

WebGemcitabine (GEM) was employed to promote ferroptosis, and ferroptosis levels were determined by monitoring lipid reactive oxygen species (ROS), cell survival, and intracellular Fe 2+ concentrations. To assess in vivo tumor response to GEM therapy, a xenograft tumor mouse model was utilized. WebApr 1, 2024 · Moreover, little literatures explored the relationship between ferroptosis and gemcitabine. Therefore, it is urgent to investigate the underlying effect of ferroptosis on pancreatic cancer and the promising value on cancer therapy. ARF6 belongs to the Ras superfamily and encodes small guanine nucleotide-binding proteins (GTP-binding protein). new holiday in 2022

Chrysin induces autophagy-dependent ferroptosis to increase ...

WebApr 12, 2024 · Ferroptosis combined with immunity shows a pivotal role in a variety of tumors, which provides new opportunities to detect and treat breast cancer.Methods: Our first step was to combine multiple datasets to search for immune ferroptosis-related mRNAs. ... Doxorubicin, Cisplatin, Gemcitabine, Gefitinib, Imatinib, Vinorelbine) in … WebOct 10, 2024 · In this article, we reviewed gemcitabine-resistance mechanisms; assessed the relationship among ferroptosis, tumorigenesis and gemcitabine resistance, and … WebJun 30, 2024 · Abstract. Ferroptosis is a new form of programmed cell death characterized by the accumulation of iron-dependent lethal lipid peroxides. Recent discoveries have … new holiday homes for sale uk

Ferroptosis: At the Crossroad of Gemcitabine Resistance …

Ferroptosis in cancer therapy: a novel approach to …

WebMay 24, 2024 · Docetaxel resistance seriously affects its clinical application in prostate cancer (PCa). Ferroptosis is a type of iron-dependent cell death driven by lipid … WebMar 4, 2024 · Accumulating studies have implicated that dysfunctional ferroptosis is involved in the progression of numerous human diseases and pathogenic processes 12, including carcinogenesis,... new holiday hoursWebOct 10, 2024 · Ferroptosis has been found to play a role in different cancers, including head and neck, and pancreatic cancer and hepatocellular carcinoma. … intex hot tub air leak

"WebGemcitabine (GEM), an antimetabolite that terminates DNA synthesis, is commonly used in the treatment of cancers including lung adenocarcinoma (LUAD). However, downregulation of sensitivity limits the therapeutic effect. " - Gemcitabine and ferroptosis

Gemcitabine and ferroptosis

Machine learning revealed ferroptosis features and …

WebJan 24, 2024 · Gemcitabine pretreatment inhibits ferroptosis in diverse cell types. Cell death in p53 wild-type Caki-1 cells and p53 mutant H1299 cells upon treatment with the indicated conditions. Nutlin-3 and gemcitabine were used as pretreatments for 48 h before addition of erastin2. Cell death was measured 24 h (Caki-1) or 36 h (H1299) after … WebApr 1, 2024 · Ferroptosis is an iron-dependent form of nonapoptotic cell death, which is characterized by lipid peroxidation. Ferroptosis has been proved to link to diversified …

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WebAug 1, 2024 · Ferroptosis refers to iron-dependent, specialized, and regulated-necrosis mediated by lipid peroxidation, which is closely related to a variety of diseases, including cancer. Tumor cells undergo extensive changes in lipid metabolism, including lipid peroxidation and ferroptosis. WebMay 13, 2024 · Ferroptosis is a novel and unique non-apoptotic cell death form, which is different from apoptosis, necrosis and autophagy, involving iron-dependent ROS formation and lipid oxidation (Yang and Stockwell, 2016). Activation of ferroptosis observed in cancer contributed to destroying the cancer cells (Dixon et al., 2012).

WebThe role of ferroptosis regulators in the prognosis, immune activity and gemcitabine resistance of pancreatic cancer The role of ferroptosis regulators in the prognosis, immune activity and gemcitabine resistance of pancreatic cancer Authors WebNov 13, 2024 · Ferroptosis is characterized by iron-dependent accumulation [ 9 ]. Thus, intracellular iron levels were determined in HCT116 and DLD-1 cells by using a Fe 2+ iron probe known as FerroOrange. The...

WebJun 30, 2024 · ACSL4, 15-LOX, and GPX4 are key factors involved in ferroptosis and lipid metabolism that regulate tumor initiation, development, invasion, metastasis, chemoresistance, and radioresistance. GPX4... WebJun 30, 2024 · Ferroptosis is a strictly regulated process involving various signaling pathways and regulators in different organelles, including mitochondria, lysosomes, and the Golgi apparatus ( Chen et al., 2024b ). In the following sections, we will review the specific functions of several important organelles in the regulation of ferroptosis.

WebDOI号:10.1016文献链接:j.bcp.2024.114813文献作者:备注信息: Chrysin induces autophagy-dependent ferroptosis to increase chemosensitivity to gemcitabine by targeting CBR1 in pancreatic cancer cells

WebMay 20, 2024 · The mechanism of ferroptosis mainly relies on intracellular dynamically balanced biochemical processes: the production and elimination of lipid peroxides. In … intex hot tub assemblyWebJan 1, 2024 · Activation of ferroptosis or apoptosis could potentiate cytotoxic effect of gemcitabine, while FBW7 promoted both ferroptosis and apoptosis. Thus, we … new holiday inn bismarck ndWebA growing body of evidence shows that ferroptosis plays a complex role in cancer, depending on the stage and the microenvironment of the tumor. While the current data are only preclinical, ferroptotic cell death may play a dual role in inhibiting or promoting PDAC formation during oncogenic KRAS activation. new holiday homes in dubaiWebOct 10, 2024 · In the past few decades, gemcitabine has been at the forefront of treatment for pancreatic ductal adenocarcinoma, but more strategies to combat drug resistance … intex hot tub cleaningWebSep 9, 2024 · Ferroptosis is a form of iron-dependent regulatory cell death caused by excessive lipid peroxidation and subsequent plasma membrane rupture [ 4, 5, 6 ]. Studies have found that tumour cells require more iron than normal cells and are more susceptible to ferroptosis, making ferroptosis a new target to treat drug-resistant cancer [ 7, 8, 9 ]. intex hot tub bubbles not workingWebMany chemotherapeutic drugs can induce ferroptosis in addition to their primary action (e.g., cisplatin, gemcitabine, sorafenib); in preclinical cancer models their action is increased by co-treatment with ferroptosis inducers, such as drugs that inhibit System Xc −, reduce GSH, inhibit GPX4, or alter intracellular iron levels (Su et al ... new holiday innWebGemcitabine (GEM), an antimetabolite that terminates DNA synthesis, is commonly used in the treatment of cancers including lung adenocarcinoma (LUAD). However, … new holiday hotels in chicago il