Ctcf isoform

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August undefined, 2024

WebMar 11, 2014 · CCCTC-binding factor (CTCF) is a DNA-binding protein that has various, often seemingly contradictory, roles in gene regulation. This Review describes these … WebSequence & Isoform; Similar Proteins; P49711 · CTCF_HUMAN. Protein. Transcriptional repressor CTCF. Gene. CTCF. Status. UniProtKB reviewed (Swiss-Prot) Organism. …

Ctcf CCCTC-binding factor [ Mus musculus (house mouse) ]

WebAn alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis. CTCF plays key roles in gene regulation, … WebApr 1, 2024 · CTCF genomic sites containing the CTCF short isoform fail to stop cohesin extrusion, leading to genome-wide decrease in cohesin occupancy [ 49, 50]. It is unclear whether differential expression of the CTCF short isoform during development or in response to stimuli represents a strategy used by cells to regulate CTCF function. canon mg2520 scanner software download

Transcription (biology) - Wikipedia

WebApr 4, 2024 · NM_001191022.2 → NP_001177951.1 transcriptional repressor CTCF isoform 2. Status: REVIEWED. Description Transcript Variant: This variant (2) lacks … WebThe .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. WebTranscriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [5] [6] CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V (D)J recombination [7] and regulation of chromatin architecture. [8] flagstaff arizona mountain biking

An alternative CTCF isoform antagonizes canonical CTCF …

National Center for Biotechnology Information

WebNational Center for Biotechnology Information WebAug 2, 2024 · CTCF is developmentally regulated, and interaction between the CTCF and these lineage-specific protein partners confers various functions during cell development and differentiation, ranging from embryonic stem cells (ESCs) to immune and muscle cells. flagstaff arizona campgrounds rv parksWebFeb 28, 2005 · A control pSG5 plasmid that does not express CTCF was also exploited to establish the basal focus-forming potential of cells in the absence of any exogenous CTCF isoform. Twenty-four hours post-transfection, cells were subjected to G418 selection and two weeks later the number of colonies was counted. canon mg2520 print head alignment

"Web5.1 CTCF genome organizer and the cohesin complex. CTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic … " - Ctcf isoform

Ctcf isoform

WebJun 23, 2024 · CTCF - an acronym for “CCCTC-binding factor” identified by Lobanenkov et. al. (Eur. J. Biochem. 1986) - is a highly conserved and ubiquitous protein with multivalent 11 Zn Fingers responsible for... WebHere, we explore the functions of an alternatively spliced human CTCF isoform in which exons 3 and 4 are skipped, producing a shorter isoform (CTCF-s). Functionally, we find …

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WebDec 20, 2024 · Moreover, CTCF interaction with the PARP-1 protein stimulates its enzymatic activity independently of DNA damage [42,45]. ... (ATM) kinase. The H1.2 isoform protects chromatin from aberrant ATM loading and activation in basal conditions. Upon DNA damage, PARP-1 covalently modifies H1.2 at the S188 residue, ... WebNational Center for Biotechnology Information

WebThe short isoform CCAT1-S is also referred as CCAT 1 or cancer-associated region long noncoding RNA-5 (CARLo-5), it is named as CCAT1-S after the long isoform CCAT1-L is discovered . ... (CTCF), regulating the intra-chromosomal interaction of well-studied oncoproteins c-MYC causing CRC tumorigenesis. WebMar 3, 2024 · ChIP-seq identifies sites of BRD8 and CTCF occupancy genome-wide. A, B, The top 7 enriched motifs under BRD8 (A) or CTCF (B) ChIP-seq peaks in Calu-3 cells. Motifs are ranked by their % incidence in target and background regions. ... (Isoform-1, −2, −4 to −7)(Jiang et al., 2016), our RNA-seq analysis identified Isoform-1 and −4 ...

WebApr 4, 2024 · Identification of an alternatively spliced CTCF-s isoform in the human genome. a Schematic representation of exons of the human CTCF gene. Transcripts including alternative exons 3 and 4 encoded ... WebApr 4, 2024 · Identification of an alternatively spliced CTCF-s isoform in the human genome. a Schematic representation of exons of the human …

WebApr 12, 2024 · Putative motifs of CTCF’s zinc fingers identified by interpreting wild-type versus mutant differential peak prediction models. To identify motifs related to the binding of each ZF in CTCF, we trained and interpreted a neural network for predicting whether a peak would be significantly weaker according to DESeq2 [] in the mutant dataset than in the …

WebTopologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins. ... article] [Google Scholar] 12. Revenkova E, Eijpe M, Heyting C, Gross B, Jessberger R. Novel meiosis-specific isoform of mammalian SMC1. Mol Cell Biol 2001; 21: 6984–6998. [PMC free article] [Google … flagstaff arizona house for saleWebNov 30, 2010 · CTCF paralog; CTCF-like protein; Cancer/testis antigen 27 (CT27) Zinc finger protein CTCF-T; Gene names. Name. CTCFL. Synonyms. BORIS. Organism … canon mg2520 color photo printer ink typeWebCpG methylation, p53 and CTCF are responsible for BORIS isoform repression in somatic cells. (A) BORIS isoform expression is activated by 5-aza-dC treatment of Normal Human Dermal Fibroblasts... canon mg2520 scan softwareWebNov 30, 2010 · CTCF paralog; CTCF-like protein; Cancer/testis antigen 27 (CT27) Zinc finger protein CTCF-T; Gene names. Name. CTCFL. Synonyms. BORIS. Organism names. Organism. ... Computationally mapped potential isoform sequences. There are 4 potential isoforms mapped to this entry. BLAST Align Add View all. Entry Entry name Gene name … flagstaff arizona hotels by reiWeba short CTCF isoform lacking the N-terminus and 2.5 zinc ngers of CTCF which is encoded by an alterna-tively spliced transcript skipping exons 3 and 4 (Li et al. 2024). CTCF genomic sites bound by the CTCF short isoform might fail to stop cohesin-mediated loop extru - sion in the genome. ese observations suggest that Open Access flagstaff arizona lodges and resortsWebApr 14, 2024 · Numerous studies have shown that CTCF regulates enhancer–promoter interactions and the human genome contains thousands of CTCF binding sites ... Variation in eNEMAL level leads to minor changes in MALAT1 expression, but a significantly higher abundance of the long isoform of NEAT1-lncRNA (NEAT1_2) is seen when eNEMAL is … flagstaff arizona hotels tripadvisorWebTranscription is the process of copying a segment of DNA into RNA. The segments of DNA transcribed into RNA molecules that can encode proteins are said to produce messenger RNA (mRNA). Other segments of DNA are copied into RNA molecules called non-coding RNAs (ncRNAs). mRNA comprises only 1–3% of total RNA samples. Less than 2% of … flagstaff arizona night clubs