Cisplatin ototoxisch

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August undefined, 2024

WebMar 29, 2024 · Cisplatin-Induced Ototoxicity: A Concise Review of the Burden, Prevention, and Interception Strategies. March 15, 2024 ARTICLE CITATION. DOI: 10.1200/OP.23.00120 JCO Oncology Practice - published online before print March 29, 2024 PMID: 36989461. Hear Me Out: Mitigating Cisplatin-Induced Ototoxicity ... WebApr 4, 2024 · While cisplatin remains a popular cancer chemotherapeutic, it has an irreversible ototoxic effect on patients’ auditory system. However, there is a paucity of epidemiological information on its extent and severity during cervical cancer treatment.

Cells Free Full-Text Cisplatin-Induced Ototoxicity in …

WebSep 18, 2024 · NCBI Bookshelf WebApr 4, 2024 · While cisplatin remains a popular cancer chemotherapeutic, it has an irreversible ototoxic effect on patients’ auditory system. However, there is a paucity of … foamed pvc flooring mat

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WebFeb 26, 2024 · The cisplatin ototoxicity occurs between 23% and 50% in adults and up to 60% in children [4,6]. However, some studies have reported elevated hearing thresholds in up to 100% of cisplatin-treated cancer patients [7,8], while it is estimated to be 63% with aminoglycosides and 6-7% with furosemide . In addition, incidence severity of ototoxic ... WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … WebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to … greenwich thai restaurant

Cisplatin - an overview ScienceDirect Topics

Serum platinum levels and cisplatin induced ototoxicity among …

WebSerum platinum levels and cisplatin induced ototoxicity among pediatric germ cell tumor survivors. Lacy Pehlke. MPH, Epidemiology. Co-Authors: Jen Poynter, Michelle Roesler & Jeannette Sample ... We will measure the association between blood serum platinum levels and ototoxicity, while adjusting for age at treatment, time since diagnosis, tumor ... WebApr 26, 2024 · Cisplatin is a highly effective antineoplastic agent used to treat solid tumors. Unfortunately, the administration of this drug leads to significant side effects, including … greenwich things to do with kidsWebMar 29, 2024 · Platinum-based agents are a standard chemotherapy treatment for malignancies in both pediatric and adult populations. 1 However, mitigating and managing chemotherapy-associated adverse events remains a concern. 2 Ototoxicity is a well-documented side effect of these platinum-based agents, especially cisplatin. This … greenwich the woolwich centre

"WebDec 19, 2024 · Despite ototoxicity being a prevalent consequence of cisplatin chemotherapy, little guidance exists on interventions to prevent this permanent and progressive adverse event. To develop a clinical practice guideline for the prevention of cisplatin-induced ototoxicity in children and adolescents with cancer, we convened an … " - Cisplatin ototoxisch

Cisplatin ototoxisch

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

WebMay 19, 2016 · He is actively involved in several human clinical trials looking at the prevention of cisplatin ototoxicity that may drastically decrease … Webcisplatin-alone group, indicating a 48% lower incidence of hearing loss in the cisplatin– sodium thiosulfate group (relative risk, 0.52; 95% confidence interval [CI], 0.33 to 0.81; P=0.002).

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WebMay 11, 2012 · Cisplatin is a prescription medicine used alone to treat bladder and ovarian cancer.It is also used together with other drugs to help treat testicular cancer, locally … WebAug 31, 2016 · Cisplatin ototoxicity is produced by several distinct mechanisms [ 16] as depicted in Figure 1. One such mechanism, the antioxidant model, involves the formation …

WebFeb 11, 2024 · Cisplatin is used to treat a wide range of childhood cancers and cisplatin-induced hearing loss (CIHL) is a common and debilitating toxicity. We aimed to address persistent knowledge gaps in CIHL by establishing benchmarks for the prevalence of and risk factors for CIHL. Methods WebMar 15, 2024 · Cisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head …

WebSep 1, 2024 · Cisplatin for injection can cause severe hypersensitivity reactions, including anaphylaxis and death. Manifestations have included facial edema, wheezing, tachycardia, and hypotension. Hypersensitivity reactions have occurred within minutes of administration to patients with prior exposure toCisplatin for injection. WebJul 9, 2024 · cisplatin exposure are the primary reasons that cause ototoxicity by creating serious damage in hair cell membranes [2]. The anti-in ammatory, anti-allergic, anti-viral, and anti-carcinogenic...

WebCisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers. Approximately 500,000 patients diagnosed annually with these cancer types in the United States could be candidates for treatment with cisplatin. There is a 5-fold increase in the …

WebJul 3, 2024 · However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been fully elucidated. It is generally accepted … greenwich thriftyWebFeb 14, 2024 · The National Comprehensive Cancer Network (NCCN) has updated clinical practice guidelines for Adolescent and Young Adults (AYA) Oncology to include sodium thiosulfate injection (Pedmark) to aid in mitigating the risk of cisplatin-associated ototoxicity in pediatric patients with localized, non-metastatic solid malignancies. 1 greenwich tick controlWebPreventing, Monitoring, and Managing Ototoxicity Related to Cisplatin: Proactive Rather Than Reactive Approaches Are Needed JCO Oncol Pract . 2024 Apr 5;OP2300116. doi: 10.1200/OP.23.00116. greenwich tick treatmentWebSep 20, 2024 · The most common adverse reactions in the two trials (≥25% with difference between arms of >5% compared to cisplatin alone) were vomiting, nausea, decreased … foameeWebSep 21, 2024 · Cisplatin and other platinum compounds are essential chemotherapeutic agents for the treatment of many pediatric malignancies. Unfortunately, platinum-based therapies can cause ototoxicity, or... greenwich thrift shopWebApr 3, 2024 · Overall, hearing impairment shows a 5-fold higher risk with cisplatin use. “Ototoxicity can manifest as tinnitus, hearing loss in the high-frequency range (4000 to … greenwich things to doWebFeb 14, 2024 · The National Comprehensive Cancer Network (NCCN) has updated clinical practice guidelines for Adolescent and Young Adults (AYA) Oncology to include sodium … greenwich thrift shop hours